Sep 202012
 

Sexually transmitted infections refers to the mode of transmission of infection and the the reproductive tract infection refers to the site where the infection occurs. All Reproductive tract infections cannot be sexually transmitted infections.

The STI are spread through sexual contact with infected partners and the common examples include:

  • Gonorrhoea
  • Chylamydia
  • Syphilis
  • Trichomoniasis
  • Chancroid
  • Genital herpes
  • Genital warts caused by HPV

Risk factors

  • Age less than 25 years
  • Young age at first sex
  • Non barrier contraception method
  • New, multiple or symptomatic sexual partners.

Incidence

The incidence of STD’s is increasing by 10% every year where safe sex practices are being ignored. 448 million new cases of curable STD’s occur annually through out the world in persons aged 15 to 49 years.

Women at more risk

Women are physiologically more vulnerable than men. If they are asymptomatic they might not seek proper medical care and later it may lead to serious complications. Use of traditional vaginal medications and douching may also increase the risk for acquiring the STD’s in women.  With the exception of HIV all STD’s have more threatening consequences in women than in men. In women it usually leads to infertility, ectopic pregnancy and cervical cancer.

Clinical Presentation

Patient with a STI usually presents with one of theses symptoms:

  • Vaginal or urethral discharge.
  • Genital lesions
  • Genital warts
  • HIV
  • Infertility

History and Physical Examination

During the history and physical examination it is important to ask about the timing of last intercourse, contraceptive method used, number of sexual partners, duration of relationship, past STD”S, menstrual and medical history as well as any antimicrobial treatment taken by the patient. Continue reading »

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Sep 162012
 

There is no specific test for the diagnosis of rheumatoid arthritis but a number of different investigations are helpful. When ever a patient i suspected to have rheumatoid arthritis on the basis of clinical symptoms and physical examination following tests are usually ordered:

1. RA Factor

Rheumatoid(RA)  factor is an IgM autoantibody against Fc fragment of IgG and is present in about 70% of cases of rheumatoid arthritis. RA factor is not specific as it may be positive in other connective tissues disorders as well.  Presence of RA factor thus does not establish the diagnosis but it can be of prognostic value with patients who have a high titre having a more severe  and progressive disease with extra articular manifestations.

2. ANA

Antinuclear antibodies (ANA) are positive in 30% of cases of rheumatoid arthritis.

3. Blood CP

Complete blood count shows anemia and thrombocytosis in proportion to the severity of joint inflammation. White cell count may be normal, high or low.

3. ESR

ESR is raised in proportion to the activity of inflammatory process. Other markers of inflammation like C-reactive protein are also raised.

4. Radiography

X rays taken during the first six months of the disease are usually normal. The earlies changes on x ray are seen in the wrist or feet and consists of :  Continue reading »

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Sep 152012
 

Herpes Simplex virus infection may be caused by type I or type II virus and the infection may be primary or recurrent.

Primary Infection

The manifestations of primary Infection includes:

1. Systemic infection: e.g fever, sore throat and lymphadenopathy that may pass unnoticed. If the patient is immunocompromised, then the disease may become life threatening with fever, lymphadenopathy, pneumonitis and hepatitis.

2. Gingivostomatitis: Ulcers filled with yellow slough appear in the mouth.

3. Herpetic Whitlow: A breach in the skin that may be due to any minor trauma allows the virus to enter the finger, causing a vesicle to form. Often this condition is seen in children nurses.

4. Traumatic Herpes: Also known as Herpes gladiatorum. In this condition vesicles develop at any site where herpes simplex virus have been inoculated on the skin by brute force.

5. Eczema Herpeticum: HSV infection superimposed on eczematous skin. Usually seen in children.

6. Herpes Simplex Meningitis: This is uncommon and if occurs it is usually self limiting.

7. Genital Herpes: It is usually caused by HSV type II. In males it presents as grouped vesicles and papules that develop around anus and penis associated with fever, pain and dysuria. In females the symptoms are more severe and there are blisters and vesicles appearing on the on the external genitalia, labia majora, labia minora, vaginal vestibule, and introitus. In moist areas, the vesicles rupture, leaving exquisitely tender ulcers. The vaginal mucosa is inflamed and edematous. There is severe burning and pain on micturition and there is associated flu like symptoms including fever, headache and lymphadenopathy.  Continue reading »

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